First published in Equine Guelph’s 20th Research Annual – January 11, 2023
Two studies led by Dr. Judith Koenig and her team at the Ontario Veterinary College have shown equine pooled cryopreserved umbilical cord blood, (eCB) MSC, to be safe and effective in treating joint pain and inflammation. Both studies received funding from Equine Guelph.
In the first study, the stem cells harvested from multiple donors of equine umbilical cord blood, (eCB), (kindly provided by eQcell), MSC were compared to saline injections in research horses. “This type of cells is much more practical if you have a cell bank,” says Koenig. “You can treat more horses with it and it’s off the shelf.” With no systemic reactions, the green light was given for the second study to test stem cell therapy in horses with lameness due to fetlock osteoarthritis.
Effectiveness of treatment in the second study was conducted by a lameness evaluator that was blinded to whether the horses received stem cell treatment or the saline placebo. “Being consistent in creating the same size chip surgically in the horses prior to treatment and exercise was a challenge,” said Koenig. The four-month study necessitated considerable manpower, with six standardbreds receiving equal daily exercise on treadmills following up with MRI’s.
MRI’s, xrays, ultrasounds and weekly lameness evaluations revealed signs of osteoarthritis improved in the group treated with (eCB) MSC’s. After six weeks of treatment, the arthroscopic score was also significantly lower in the MSC group compared to the control group.
Another trial with six horses is planned for Spring 2023. The initial findings are very exciting for the future possibilities of treating equine osteoarthritis with stem cell therapy.
Equine Guelph is pleased to support a number of high-quality projects at the University of Guelph, by virtue of funding provided largely by the racing industry (Standardbred, Thoroughbred and Quarter horse organizations): the Horse Improvement Program from the Horsemen’s Benevolent and Protective Association, and the E.P. Taylor Foundation, started by veterinarians in the Thoroughbred industry, and now maintained in trust by the University and Equine Guelph.
Full publication of the 20th Equine Guelph Research Annual
Notes to Editor:
Equine Guelph is the horse owners’ and care givers’ Centre at the University of Guelph in Canada. It is a unique partnership dedicated to the health and well-being of horses, supported and overseen by equine industry groups. Equine Guelph is the epicentre for academia, industry and government – for the good of the equine industry as a whole. For further information, visit www.equineguelph.ca.
Story by: Jackie Bellamy-Zions, Equine Guelph
Photos: (images available upon request). MRI images, Horse in MRI machine.
Photo Credit: Dr. Judith Koenig
Photo Caption: Horses in the MSC group had lower MRI Whole-Organ Magnetic Resonance Imaging Scores and lower radiographic osteoarthritis scores.
Story web link: https://thehorseportal.ca/2023/01/strong-support-for-future-use-of-stem-cells-to-treat-equine-osteo-arthritis/
Other web links:
Equine Guelph Annual Research Update Volume 20– 2023
YouTube video: https://youtu.be/rhsvcNN2_sk
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